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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in
《医学前沿(英文)》 页码 939-956 doi: 10.1007/s11684-023-0987-9
关键词: mononuclear diploid cardiomyocytes cell–cell communication cardiac fibroblast single-cell RNA sequencing cardiac regeneration
Integrated management of cardiac failure: the cardiac failure clinic
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 20-25 doi: 10.1007/s11684-011-0106-1
The prevalence of the risk factors and the risk of cardiac failure are both increasing in China. This might be the consequence of the changes of the life conditions (emigration to the urban areas, changes in the diet and life style, lack of physical exercise, etc.). The wide range of clinical presentations of cardiac failure (acute or chronic) and of therapeutic approaches (medical or surgical) makes necessary the integration within the same structure of the various experts involved in the diagnosis and the treatment of cardiac diseases. Technologic and human resources required to offer all the options represent a multifaceted commitment which should be focused optimally in dedicated centers. In these centers, collaboration should replace competition between the medical and the surgical cardiac specialists. Development of team work should permit to optimize the cost efficacy of the treatments. Most of all, such a structure will facilitate the translation of innovative therapies between the research centers and clinical facilities.
关键词: cardiac failure cardiac transplantation mechanical circulatory support
生物材料在心脏修复和再生中的应用 Review
Zhi Cui,Baofeng Yang,Ren-Ke Li
《工程(英文)》 2016年 第2卷 第1期 页码 141-148 doi: 10.1016/J.ENG.2016.01.028
心血管疾病是全世界主要致死原因之一。人们对新的干预性治疗手段的需求与日俱增。虽然药物和手术治疗极大地改善了心血管疾病患者的生活质量,但人们还是需要价格更便宜、副作用更小的治疗手段。天然和合成生物材料无论是作为给药载体,还是替代支架的细胞外基质,在心脏修复和再生中都展现出巨大的潜力。本文探讨了目前治疗心血管疾病的几种方式和应用于上述疾病干预性治疗的生物材料;着重研究了导电聚合物在纠正局部缺血性心脏病引发的传导异常及其在心脏起搏器中应用的可能性,以改善心肌梗死状态下的传导路径。
《医学前沿(英文)》 2023年 第17卷 第1期 页码 58-67 doi: 10.1007/s11684-022-0937-y
关键词: cardiac disease mortality aged population lung transplantation
Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 254-258 doi: 10.1007/s11684-014-0319-1
Mantle cell lymphoma is an aggressive subtype of B cell non-Hodgkin lymphoma. It can progress to leukemic phase but frank leukemic picture at initial presentation is not common. Leukemic phase indicates advance stage of the disease and generally associated with extensive extra-nodal involvement. Pericardial invasion has been reported, however we could not find a report of myocardial infiltration by this disease since the appraisal of the term “mantle cell lymphoma” in 1992. Here we report a case of cardiac involvement by mantle cell leukemia leading to cardiogenic shock which complicates the treatment decisions.
ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen
《医学前沿(英文)》 2008年 第2卷 第1期 页码 19-24 doi: 10.1007/s11684-008-0005-2
关键词: therapy Sprague administration cardiac hypertrophy valsartan
null
《医学前沿(英文)》 2014年 第8卷 第4期 页码 445-455 doi: 10.1007/s11684-014-0378-3
Recent evidences suggested that cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5) inhibitor represents an important therapeutic target for cardiovascular diseases. Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failure, is unknown. The purpose of this study was to investigate the effects of PDE5 inhibitor on cardiac fibrosis. We assessed cardiac fibrosis and pathology in mice subjected to transverse aortic constriction (TAC). Oral sildenafil, a PDE5 inhibitor, was administered in the therapy group. In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiac fibroblast activation (proliferation and transformation to myofibroblasts). Sildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiac fibroblast activation but did not block TAC-induced transforming growth factor-β1 (TGF-β1) production and phosphorylation of Smad2/3. In isolated cardiac fibroblasts, sildenafil blocked TGF-β1-induced cardiac fibroblast transformation, proliferation and collagen synthesis. Furthermore, we found that sildenafil induced phosphorylated cAMP response element binding protein (CREB) and reduced CREB-binding protein 1 (CBP1) recruitment to Smad transcriptional complexes. PDE5 inhibition prevents cardiac fibrosis by reducing CBP1 recruitment to Smad transcriptional complexes through CREB activation in cardiac fibroblasts.
关键词: PDE5 cardiac fibrosis TGF-β CREB
Migration of manganese and iron during the adsorption-regeneration cycles for arsenic removal
Fangfang CHANG, Jiuhui QU, Xu ZHAO, Wenjun LIU, Kun WU
《环境科学与工程前沿(英文)》 2011年 第5卷 第4期 页码 512-518 doi: 10.1007/s11783-011-0372-9
Bin Yu, Xiaosong Gu
《医学前沿(英文)》 2019年 第13卷 第2期 页码 131-137 doi: 10.1007/s11684-018-0642-z
关键词: spinal cord injury biomaterial extrinsic barrier intrinsic regeneration capacity
Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region
Zhiyuan Zhang
《医学前沿(英文)》 2011年 第5卷 第4期 页码 401-413 doi: 10.1007/s11684-011-0161-7
关键词: bone regeneration animal models translational strategies oral and maxillofacial region
SHI Mingheng, DU Bin, ZHAO Yun
《能源前沿(英文)》 2007年 第1卷 第1期 页码 85-90 doi: 10.1007/s11708-007-0008-8
关键词: desiccant air-conditioning regeneration process air-conditioning system energy regeneration
Evaluation of power regeneration in primary suspension for a railway vehicle
Ruichen WANG, Zhiwei WANG
《机械工程前沿(英文)》 2020年 第15卷 第2期 页码 265-278 doi: 10.1007/s11465-019-0571-9
关键词: railway vehicle primary damper power regeneration ride comfort running safety
Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 237-249 doi: 10.1007/s11684-016-0464-9
Sensory hair cells in the inner ear are responsible for sound recognition. Damage to hair cells in adult mammals causes permanent hearing impairment because these cells cannot regenerate. By contrast, newborn mammals possess limited regenerative capacity because of the active participation of various signaling pathways, including Wnt and Notch signaling. The Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multiple cellular events necessary for the formation of sensory hair cells. Both signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochlea. In this regard, Wnt and Notch signaling has gained increased research attention in hair cell regeneration. This review presents the current understanding of the Wnt and Notch signaling pathways in the auditory portion of the inner ear and discusses the possibilities of controlling these pathways with the hair cell fate determiner Atoh1 to regulate hair cell regeneration in the mammalian cochlea.
关键词: inner ear cochlea hair cell regeneration Wnt Notch signaling pathways
Electro-assisted regeneration of ion exchange resins
LIU Zhigang, WANG Ying, LI Yansheng, CHANG Hui
《环境科学与工程前沿(英文)》 2008年 第2卷 第4期 页码 410-414 doi: 10.1007/s11783-008-0069-x
关键词: effluent volume acidic three-compartment weakly exchange
Sulfidation/regeneration multicycle testing of nickel-modified ZnFe
Wei LI, Jinju GUO, Jiejie HUANG, Jiaotao ZHAO
《化学科学与工程前沿(英文)》 2010年 第4卷 第4期 页码 435-440 doi: 10.1007/s11705-010-0506-9
关键词: hot gas desulphurization nickel-modified ZnFe2O4 sulfidation/regeneration
标题 作者 时间 类型 操作
Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in
期刊论文
Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients
期刊论文
Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy
ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen
期刊论文
Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis
null
期刊论文
Migration of manganese and iron during the adsorption-regeneration cycles for arsenic removal
Fangfang CHANG, Jiuhui QU, Xu ZHAO, Wenjun LIU, Kun WU
期刊论文
biomaterial transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration
Bin Yu, Xiaosong Gu
期刊论文
Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region
Zhiyuan Zhang
期刊论文
Investigation on regeneration and energy storage characteristics of a solar liquid desiccant air-conditioning
SHI Mingheng, DU Bin, ZHAO Yun
期刊论文
Evaluation of power regeneration in primary suspension for a railway vehicle
Ruichen WANG, Zhiwei WANG
期刊论文
Electro-assisted regeneration of ion exchange resins
LIU Zhigang, WANG Ying, LI Yansheng, CHANG Hui
期刊论文